Canadian Manufacturing

Bringing drugs to the brain with nanoparticles to treat neurodegenerative diseases

Researchers believe these results will open important prospects for releasing drugs directly to the brain

November 9, 2020  by CM Staff

INRS Professor Charles Ramassamy and postdoctoral researcher Jean-Michel Rabanel. (Institut national de la recherche scientifique (INRS))

MONTREAL and LAVAL, Que. — Researchers from the Institut national de la recherche scientifique (INRS) have shown that nanoparticles could be used to deliver drugs to the brain to treat neurodegenerative diseases.

According to a recent study conducted by Jean-Michel Rabanel, a postdoctoral researcher under the supervision of Professor Charles Ramassamy, nanoparticles with specific properties could cross this barrier and be captured by neuronal cells. Researchers believe these results will open important prospects for releasing drugs directly to the brain.

“The blood-brain barrier filters out harmful substances to prevent them from freely reaching the brain. But this same barrier also blocks the passage of drugs,” explained pharmacologist Charles Ramassamy, in a prepared statement. Typically, high doses are required to get a small amount of the drug into the brain. What remains in the bloodstream has significant side effects. Often, this discomfort leads the patient to stop the treatment.  The use of nanoparticles, which encapsulate the drugs, would result in fewer collateral side effects while increasing brain efficiency. 

To prove the effectiveness of this method, the research team first tested it on cultured cells, then on zebrafish.

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“This species offers several advantages. Its blood-brain barrier is similar to that of humans and its transparent skin makes it possible to see nanoparticles’ distribution almost in real time,” said Ramassamy.

Using in vivo tests, researchers were able to observe the crossing of the blood-brain barrier. They also confirmed the absence of toxicity in the library of selected nanoparticles. “We made the particles with polylactic acid (PLA), a biocompatible material that is easily eliminated by the body. A layer of polyethylene glycol (PEG) covers these nanoparticles and makes them invisible to the immune system, so they can longer circulate in the bloodstream,” he explains. After several years of research on effective and safe nanoparticles, the research team will continue laboratory testing, targeting the delivery of active ingredients to other animal models with ultimate clinical applications.