Canadian Manufacturing

MilliporeSigma announces increased capacity to advance antibody-drug conjugate therapies

These initiatives emphasize MilliporeSigma's continued investment in novel modalities and support the company's efforts to double its ADC and high-potent active pharmaceutical ingredient (HPAPI) capacity in the near future.

October 28, 2021  by CM Staff

MilliporeSigma, the U.S. and Canadian Life Science business of Merck KGaA, Darmstadt, Germany, launches new technology and expands capacity to advance antibody-drug conjugate (ADC) therapies.

BURLINGTON — MilliporeSigma, the U.S. and Canadian Life Science business of Merck KGaA, Darmstadt, Germany, a science and technology company, announced that its Life Science business sector has launched new technology and expanded capacity to advance ADC therapies. These initiatives emphasize MilliporeSigma’s continued investment in novel modalities and support the company’s efforts to double its ADC and high-potent active pharmaceutical ingredient (HPAPI) capacity in the near future.

“ADCs have experienced remarkable growth, with commercially approved ADCs tripling in the past three years,” said Andrew Bulpin, head of Process Solutions at the Life Science business of Merck KGaA, Darmstadt, Germany. “We are a pioneer in this space, involved in 50 percent of the commercially approved ADCs on the market today. This latest innovation and additional capacity help bring novel treatments to cancer patients around the world and reinforce our commitment to shaping the future of these novel modalities.”

With the launch of its ChetoSensar™ technology, MilliporeSigma is working to address the hydrophobicity of ADCs, in tandem with its CDMO services. Many ADC candidates have poor aqueous solubility and MilliporeSigma estimates that more than 20 percent of ADC clinical terminations are caused by this issue. The company’s new ChetoSensar™ technology improves ADC solubility, therefore giving hope to ADCs that were previously terminated.

In addition, the company will enhance the ADC capabilities of its clinical manufacturing facility in St. Louis, Missouri in December. This facility will provide larger footprint to enable large-scale production including chromatographic purification for early phase clinical supply. This follows last year’s announcement of a $65 million expansion of MilliporeSigma’s facility near Madison, Wisconsin, which will double its HPAPI kilo lab capacity and enable the company to expedite the manufacture of HPAPIs, ADC linker/payloads, and complex APIs.

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MilliporeSigma recently announced expansion projects in Darmstadt, Germany; Cork, Ireland; Buchs, Switzerland; Carlsbad, California, USA; Madison, Wisconsin, USA; Jaffrey, New Hampshire, USA; and Danvers, Massachusetts, USA. These expansions are part of an ambitious, multi-year program to increase the industrial capacity and capabilities of the Life Science business sector to support growing global demand for lifesaving medications and to make significant contributions to public health.