Canadian Manufacturing

A South African company addresses vaccine supply inequity, despite Canada’s lack of support

by Matthew Herder, Director of the Health Law Institute at the Schulich School of Law, Dalhousie University; E. Richard Gold, Professor of intellectual property and innovation, Faculty of Law and Faculty of Medicine and Health Sciences, McGill University   

Manufacturing Research & Development Public Sector Global Pandemic mRNA Vaccines Patent Rights supply chain Vaccine Shortage

What many don’t realize is that two Canadian companies control a key component of the mRNA vaccines.

Afrigen uses Moderna data to make a COVID-19 vaccine.

Since late 2020, the inequitable access across the globe to COVID-19 vaccines has been a glaring problem. But a remarkable achievement earlier this month offers hope that the supply of vaccines to developing countries will improve: Afrigen Biologics, a South African based company, produced its own version of Moderna’s mRNA COVID-19 vaccine. This was achieved with no support from Moderna or Pfizer-BioNTech, the manufacturer of the other mRNA vaccine.

What many don’t realize is that two Canadian companies control a key component of the mRNA vaccines. Busy fighting over their lucrative patent rights, there is no sign they shared their technology with Afrigen either.

The two companies in question — Acuitas Therapeutics and Arbutus Biopharma — are based in Vancouver, B.C., and have strong ties to the University of British Columbia. They have been lauded for their positive “global impact” in combating the pandemic.

But that impact seems to stop short of sharing their technology with Afrigen and other would-be suppliers of COVID-19 vaccines in the Global South.

Protecting patents and profits

The mRNA vaccines are incredible innovations and the culmination of decades of research. They work because of something called “lipid nanoparticles,” (LNPs) which deliver the mRNA to its target. LNPs are also the result of many years of publicly funded research, spearheaded by scientists at the University of British Columbia and further developed by companies like Arbutus and Acuitas.

As we show in our research, the long road to developing LNPs is littered with lawsuits over patent rights and allegations of scientific theft. In the 1990s, Pieter Cullis, a biochemist at UBC, worked alongside Ian MacLachlan, another one of the inventors of the LNP delivery system, and Thomas Madden at a company called Inex.

Years later, they split up. In 2008, Madden was pushed out. He then formed a new outfit with Cullis, which became Acuitas. This precipitated a series of lawsuits between Acuitas and the company now known as Arbutus, UBC and various commercial partners, including Moderna.

Through the pandemic, Moderna and Arbutus have continued to fight over several LNP patents, with Moderna suffering a major blow in December 2021, when its appeal was rejected by the U.S. Federal Court of Appeals. Arbutus has since turned around and sued Moderna anew. Meanwhile Pfizer just inked a new deal with Acuitas for its vaccine technology.

Vaccine inequities

Lost in all of this corporate wheeling, dealing and litigating are a number of important questions: Given the scale of the ongoing pandemic, why wasn’t the LNP technology shared with Afrigen? Why didn’t the scientists who developed this foundational technology rise to that same task? Why didn’t Canada, which funded much of the foundational research, have the ability to ensure equitable access? And why didn’t UBC, lauded for prioritizing global health when commercializing technology, require that the research was made more broadly available?

In short, in the face of vaccine inequity, why not try to help?

The obvious answer is that it’s not in the companies’ financial interests. A new investigation by the British Medical Journal showed just how far industry will go to protect its profits by working surreptitiously through a foundation to undermine the World Health Organization’s newly created “technology transfer hub” in South Africa.

The Canadian companies likewise appear to have determined that it is not in their financial interests to assist vaccine makers in low- and middle-income countries. For its part, Acuitas might have been worried that if it shared the LNP technology it would breach its agreements with Pfizer-BioNTech. Having warded off Moderna’s challenge to its patents, Arbutus is positioned to license its LNP technology to additional partners. Transferring the know-how to Afrigen would diminish the asset’s value.

Lying beneath these calculations lies a troubling truth: this is exactly how the drug and vaccine innovation system was designed to work. Discover a technology, patent it and then — regardless of how much public funding supported its discovery — let the market decide how, and on what terms, its development should proceed.

This system does produce innovations like the mRNA vaccines. But in the ongoing pandemic, firms with innovative technologies use patents and other forms of intellectual property to triple dip: they retain the benefit of public dollars that went into the underlying research, they receive revenues for their product from that same public and they extort poorer countries to pay through the nose for that product.

Meanwhile, would-be producers of public health interventions such as COVID-19 vaccines not only face delays due to limited access to the underlying knowledge, but they also run the risk of being sued for patent infringement.

Fundamental changes to innovation

More details about how Afrigen overcame these challenges to produce its first doses of an mRNA vaccine are apt to emerge in the weeks ahead. Perhaps some scientists, aghast at the abject level of vaccine inequity globally, rebelled and gave Afrigen a helping hand.

However, we doubt that any of these publicly supported Canadian scientists — who possess the needed know-how — were among them. Sadly, that is not what our system teaches them to do.

In the end, Canada has not been a helpful partner in the global fight against COVID-19. It has failed to mobilize production of COVID-19 vaccines under Canada’s Access to Medicines Regime. It has failed to support a waiver of certain international trade rules to allow developing countries to manufacture their own vaccines without fear of trade-related reprisals. And Canadian companies, as best we can tell, have failed to help Afrigen scale up production of mRNA vaccines.

If we truly want out of this pandemic, and more equitable outcomes in the next, our innovation laws, policies and practices require fundamental change.

This article is republished from The Conversation under a Creative Commons license. Read the original article .


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